3D Monitoring of Hand Contractures
Three-dimensional scanning and image-analysis software quantify finger-joint geometry to follow Dupuytren’s contracture over time. The system is intended to make measurements more objective and repeatable than manual angle measurements, supporting clinical assessment, longitudinal studies and potential remote monitoring. Later development work concentrates on finger identification, measurement accuracy and pilot validation. The software forms one part of a wider research programme on fibrotic musculoskeletal conditions and their treatment.
ABCA4 Minipig Retinal-Disease Model
A genetically modified minipig model carries changes in ABCA4, a gene associated with Stargardt retinal disease. The research combines genome analysis, embryo manipulation and breeding to create and characterise animals that can reproduce relevant aspects of inherited retinal degeneration. The model is intended as a research resource for understanding disease progression and evaluating future interventions. The development work concerns transfer of the animal-model platform and associated specialist expertise, not a treatment for patients.
Accessible Czech Language Reference Platform
The Internet Language Reference Book provides an expert-supported digital resource for understanding and using Czech. The development work develops clearer navigation, content presentation and guidance for users, especially non-native speakers and international academics, together with a mobile-access route. It also addresses the rights and operating arrangements needed for sustainable reuse of the content and data. The offering combines the linguistic knowledge base with user-oriented interfaces and instructional materials.
AI Enhancement of Steel Micrographs
Artificial-intelligence models enhance light-microscope images of steel and alloy microstructures to support faster metallographic interpretation. The proposed software aims to make useful microstructural information more accessible where electron microscopy is costly or impractical. Both cloud and local deployment are envisaged for quality-control laboratories and research users. The development work concerns validation and commercial preparation of the software; the claimed improvement towards electron-microscope-like image quality remains dependent on data, training and testing.
Algae and Mould Control for Building Façades
A set of treatment formulations and application methods removes biological growth from rendered, insulated façades and helps protect the surface against renewed colonisation. The development activities focus on green algae and mould and describe preparation routes intended to be economical, practical and less burdensome than existing treatments. Transferable assets include formulation and manufacturing know-how, application procedures and partner-specific validation. The work covers both remedial cleaning and preventive surface protection for buildings.
APB Surfaces Antifouling Polymer Brushes
A controlled polymerisation process forms ultrathin polymer-brush layers that resist non-specific attachment of proteins, cells and other biological material. The surface can still be functionalised to capture a chosen target, improving the selectivity of bioanalytical measurements. The development work emphasises preparation in water at laboratory temperature to simplify manufacturing and reduce resource requirements. This is a distinct coating and process offering from FZU’s FunBRUSH platform, despite their shared focus on antifouling surfaces.
Application-Tailored Diamond Materials
Diamond fabrication and characterisation know-how is used to tailor material properties for specific device requirements. The development work identifies sensing, electronics thermal management and quantum-related research as priority directions, with the offering ranging from knowledge transfer and proof-of-concept devices to small-volume fabrication. Different uses have different development maturity. This broad diamond platform is distinct from the later, more specific surface-treatment process for high-quality (111)-oriented CVD diamond crystals.
Aqueous Batteries for Stationary Storage
An energy-storage platform combines a non-flammable water-based electrolyte with electrode-material development for stationary battery systems. The approach is intended to address safety, cost, lifetime and dependence on critical raw materials associated with existing storage technologies. The development work brings together several intellectual-property components and preparation for a spin-off. The transferable offering concerns battery materials and system know-how, with further technical validation and manufacturing development needed for specific commercial configurations.
Artificial Tear-Film Testing Platform
An in-vitro tear-film model and associated instrument reproduce selected properties of the human tear-film interface so that its stability and response to applied substances can be measured. The approach supports assessment of ocular irritation and interactions with ophthalmic formulations without relying solely on animal models. Its modular laboratory design allows additional analytical methods to be incorporated. Potential users include pharmaceutical and cosmetic developers working on eye drops, contact-lens solutions and products applied around the eye.
Atomically Flat (111) CVD Diamond
A proprietary plasma surface treatment creates atomically flat terraces that support growth of high-quality diamond crystals with a (111) orientation. Combined with controlled doping, the approach aims to supply better-defined material for semiconductor and quantum-device development, including control relevant to nitrogen-vacancy centres. The development work concerns surface preparation, diamond growth and material customisation. Commercial work will assess customer requirements, production scale-up and delivery of crystals with reproducible surface and structural properties.
Bacteriophage Protection for Greenhouse Tomatoes
This biological crop-protection platform isolates, propagates and formulates bacteriophages that target bacterial pathogens of greenhouse tomatoes, especially Pseudomonas syringae pv. tomato. A library of effective phages and associated isolation methods allows formulations to be adapted as pathogen strains or geographical requirements change. The approach is intended for both preventive and curative use and is designed to spare non-target organisms. The development work covers formulation, application procedures, scale-up partnerships and commercial preparation.
Biodegradable Magnesium Implant Wires
Magnesium and low-zinc magnesium-alloy wires, cables and ribbons are produced by extrusion to combine useful mechanical strength with gradual biological resorption. Possible designs include braided structures and functional biodegradable polymer coatings. The development work focuses on temporary fixation and surgical materials, including a prototype for sternal fixation tested in minipigs. The aim is to provide support during healing and potentially reduce the need for later implant-removal surgery, subject to further device development and validation.
Biomimetic Droplet Surface Testing
Lipid and proteolipid structures act as simplified probes of surface interactions. Later development work develops bacterium-mimicking microdroplets for supplemental screening of industrial material surfaces without culturing live bacteria. The method measures droplet adsorption and desorption to help select samples for further testing; its ability to predict bacterial adhesion or antibacterial activity has not been established. Transferable know-how includes probe preparation, measurement protocols and interpretation, with screening services envisaged for material developers.
Blood Biomarkers for Spinal-Cord Injury
A proposed blood-based assay measures four microRNAs using RT-qPCR to help distinguish the severity of traumatic spinal-cord injury during the early post-injury period. The approach is intended to provide objective information when a patient cannot cooperate with a neurological examination and to avoid reliance on invasive cerebrospinal-fluid sampling. The development work focuses on preparing the diagnostic technology for licensing, including intellectual-property review and commercial planning. Clinical and regulatory validation remain necessary for routine diagnostic use.
Bohemia Bioanalytics Bioinformatics Services
A specialist bioinformatics service would provide tailored data analysis, project support from experimental design through interpretation, and training adapted to customers’ own work. The development work emphasises expertise across diverse biological systems, including needs not well served by standard analyses built primarily around model organisms. The offering combines scientific staff, analytical workflows, quality control and consultation. It is a proposed service business rather than a single proprietary software product.
BOROSKOP High-Temperature Furnace Monitoring
BOROSKOP combines a camera, active cooling and image-processing software to observe processes inside industrial furnaces during operation. It is intended to give operators visual information for diagnostics, process optimisation and early identification of deviations without a shutdown for inspection. The development work addresses practical integration into high-temperature production environments and preparation of a distributor-based commercial route. The offering is an integrated monitoring system, including hardware, software and application-specific implementation support.
CCALA Algal and Cyanobacterial Resources
The CCALA collection supplies a diverse set of algal and cyanobacterial strains, including scientifically valuable isolates with potential for applied research and product development. The project organises how these biological resources can be made available for commercial use through documented material transfer, pricing and licensing procedures. The offering combines characterised living material with collection expertise and traceable handling. It supports organisations developing biotechnology, food, agricultural, pharmaceutical and environmental applications using microorganisms.
Charge-Resistant Electron-Microscopy Resins
Modified embedding media and preparation kits improve the behaviour of biological samples under an electron beam. The resins are designed to reduce charging and increase resistance to beam damage, improving image contrast and quality without necessarily requiring special microscope hardware. The development work addresses volume scanning electron microscopy as well as other resin-embedding workflows. The transferable package combines formulations and specimen-preparation know-how, with further customer validation and commercial-production assessment planned.
ClimRiskPRO Climate-Risk Data Services
ClimRiskPRO turns research-based climate projections into location- and project-specific information for investment planning and climate adaptation. A web-supported dialogue gathers the customer’s requirements so that suitable data and interpretation can be prepared more efficiently and repeatedly. The offering builds on the public ClimRisk platform but addresses more detailed needs relating to the location, lifetime and operating conditions of an investment. It combines data preparation, specialist interpretation and an organised consultation workflow.
Cold Spray Metal Coating and Repair
Cold spray accelerates fine powder particles to high velocity so that they bond on impact without being melted. This solid-state process can build thick metallic layers while limiting thermal damage to both the deposited material and the component underneath. The technology supports protective coatings, restoration of worn or damaged parts and additive manufacturing. The proposed commercial offering combines process expertise, material-specific development and component qualification for industrial customers.
Compact High-Temperature Creep Testing
A creep-testing machine measures the long-term deformation of materials under sustained load at high temperature. The design fits two testing units within the footprint of one conventional machine and combines direct loading, purpose-built control software and a simplified furnace arrangement. It targets stable, lower-maintenance testing with reduced space and energy requirements. The development work describes equipment already used in the institute’s laboratory and preparation for transfer to material-testing customers.
Compact Optical Tweezers Microscope Adapter
A compact adapter introduces an additional focused light beam into an optical microscope through standard objective-mount interfaces. It is intended to make optical trapping and manipulation available on existing instruments, while also supporting fluorescence excitation, laser ablation and other beam-based operations at the specimen plane. The development work describes a manufactured and experimentally tested device. Its principal value is a relatively accessible route to adding advanced optical functions without replacing the microscope.
Cooled ESEM Holder with Electron Detection
A cooled specimen holder integrates a high-efficiency ionisation detector for environmental scanning electron microscopy. It is designed for observing strongly hydrated samples under elevated water-vapour pressure, combining control of specimen temperature with collection of signal electrons. The hardware complements the thermodynamic-control software developed within the same research effort but represents a distinct instrument component. It targets improved imaging of biological and other moisture-sensitive materials in their native or near-native state.
Corrosion-Controlled Magnesium Implant Surfaces
A chemical surface-treatment process removes a controlled surface layer from magnesium or magnesium-alloy materials using a nitric-acid-based etchant. The treatment is intended to reduce unwanted corrosion and hydrogen evolution while preserving useful mechanical behaviour as an implant degrades in the body. Potential products include resorbable fixation devices, wires and surgical materials. The development work concerns the surface-treatment know-how, developed with other research partners, rather than the separate extrusion technology for manufacturing magnesium implant wires.
Cosmogenic Dating for Geological Safety
Cosmogenic-radionuclide measurements date sedimentary material and support estimates of long-term landscape erosion and uplift. The development work combines specialist sampling, accelerator mass spectrometry and age modelling to quantify denudation in the Bohemian Massif. These data are intended to improve geological assessments used in planning a deep radioactive-waste repository, including evaluation of suitable depth and long-term surface evolution. The transferable offering is an analytical and interpretation service rather than a standalone instrument.
CrysTBox Automated Crystallographic Analysis
CrysTBox uses computer vision and artificial-intelligence methods to automate crystallographic analysis and make results easier to interpret through interactive visualisation. It is designed to accelerate materials-research workflows by replacing time-consuming manual interpretation with reproducible software-assisted processing. The development work describes an established research-user base and preparation for commercial licensing, updates and technical support. The software itself is a separate offering from the institute-wide distribution platform that also supports other crystallographic programs.
Custom Scientific Instruments and Ion Optics
A specialist engineering offering combines vacuum technology, ion optics, spectroscopy, mass-spectrometric analysis, electronics and control software to build custom research instruments. The development work describes delivered systems such as quadrupole assemblies, nanoparticle detectors and generators, and transfer optics. The transferable asset is the accumulated design documentation and instrument-development know-how behind these systems. It supports customers whose experimental requirements are not met by standard catalogue instruments, including laboratories and large research facilities.
CzechGlobe Climate and Hazard Maps
A proposed mobile and web application brings together research-derived information on drought, fire risk, spring frost and future climate in one map and timeline. It combines outputs from InterSucho, FireRisk, Agrorisk and ClimRisk, with location-saving and high-risk notifications for users such as farmers, foresters and municipalities. The technology concerns integration and presentation of existing analytical outputs, supported by user testing. Its risk maps are distinct from the official warning service operated by ČHMÚ.
Deformation Sensor for Bridge Diagnostics
A proposed deformeter measures how a bridge responds to loading, supporting structural assessment and more efficient diagnostic testing. Its development is coordinated with an impulse exciter, allowing controlled loading and response measurement to be evaluated together. The development work describes integration of mechanical and electronic components, laboratory verification and planned demonstration on an existing bridge. The transferable asset is the measurement-device design and associated calibration know-how, with prototype performance still to be validated.
Digital Czech Poetry Analysis and Learning
A full-text digital library of Czech poetry combines a substantial historical corpus with tools for thematic and formal analysis. Machine-learning-assisted clustering helps users explore recurring motifs, relationships between poems and changes across authors or periods. Separate modes support teaching and expert research, connecting computational analysis with literary interpretation. The development work transfers the database, analytical interfaces and instructional expertise into wider use by schools, universities and researchers.
Digital Reconstruction of Lost Architecture
Historical and archaeological research is combined with three-dimensional modelling and visualisation to reconstruct architectural heritage that has been damaged or destroyed. The development work uses monuments in Mosul as an exhibition case, translating scholarly evidence into physical and digital interpretive material for museum audiences. The underlying offering includes the reconstruction methodology, research content and exhibition-production expertise. These capabilities can be applied to other heritage sites where reliable documentary evidence is available.
Direct Methane-to-Methanol Catalysis
A specifically structured metal-zeolite catalyst enables direct oxidation of methane to methanol using molecular oxygen under isothermal conditions, with methanol released into the gas phase. The approach aims to simplify the intermediate reaction, separation and purification steps associated with conventional routes. The development activities cover laboratory validation, intellectual-property protection and transfer towards industrial catalyst development. Its potential uses include chemical feedstock production and utilisation of methane resources, while scale-up and commercial process performance remain development tasks.
ElChem Cross-Instrument Electrochemical Analysis
ElChem is an analytical software layer that imports electrochemical data from supported instrument exports and applies a common physical framework across multiple measurement methods. It is intended to work with both new and historical datasets, quantify uncertainty and parameter identifiability, and produce expert or guided reports. The offering combines analytical modules with a proposed service workflow. The development activities describe laboratory-stage integration and plans for testing with external users and real customer data.
EMOLAB Emotional-Literacy Learning Tools
EMOLAB translates psychological research into structured activities, games and visual materials that help children and adolescents understand emotions, handle stress and develop psychological literacy. The proposed resources are largely screen-free and intended for integration into everyday school practice. The development work combines an empirically informed intervention framework with practical educational products and preparation for a spin-off. The offering is a learning and prevention toolkit, with its wider use and commercial model still being evaluated.
Engineered Cell Lines for Vaccine Research
A cell-line development platform combines genetic editing, molecular and cellular characterisation, controlled storage and traceable documentation. Initial work focuses on CRFK and MDCK lines, with the aim of producing transferable material, standard operating procedures and know-how for vaccine-related research and development. An internal CryoBase system supports recordkeeping and standardisation. The development work proposes a pilot supply and development platform; suitability for a customer’s manufacturing process requires separate partner assessment and qualification.
Environmental Microscopy Climate-Control Software
Thermodynamic simulation software predicts and visualises conditions close to a specimen inside an environmental scanning electron microscope. It uses sample properties, holder geometry and instrument settings to support choices of pressure, temperature and humidity that help retain the specimen’s native hydrated state. The development work describes an intuitive interface with AI-related functionality for rapid calculation and optimisation. Its intended value is easier operation and reduced risk of damage during observation of sensitive materials and biological samples.
Equine Embryo Production and Cryobanking
An assisted-reproduction service combines equine embryo production using ICSI and IVF with genetic characterisation, freezing, storage and distribution. The development work targets breeding of valuable horse lines and links embryo production to sex determination, testing for inherited conditions and long-term cryobanking of embryos and reproductive cells. The transferable offering is specialist laboratory know-how and a coordinated service workflow. Commercial introduction depends on reproducible production, veterinary practice requirements and cooperation with breeders.
Evidence-Based Historical AI Avatar
A proposed interactive avatar of Tomáš G. Masaryk combines a curated scholarly corpus with retrieval-supported artificial intelligence for museum and educational use. The system is intended to answer questions using historical source material and critical editions, supported by knowledge-graph retrieval and pedagogical design. The institute’s contribution is the researched and edited content and its historical interpretation. The development work also addresses the reliability, rights and operational arrangements needed for a public-facing historical experience.
Floating Photocatalyst for Water Cleaning
A buoyant composite fixes titanium-dioxide photocatalyst onto lightweight recycled foamed glass using an inorganic binder. Floating at the water surface exposes the material to light and dissolved oxygen, supporting photocatalytic breakdown of persistent organic pollutants such as pharmaceuticals, pesticides and personal-care chemicals. The design combines catalyst immobilisation with simple handling and recovery. The development work positions it for wastewater and surface-water treatment, with manufacturing and deployment know-how intended for transfer to a commercial partner.
FunBRUSH Antifouling Surface Coatings
FunBRUSH uses functional terpolymer brushes to form ultrathin surface layers that resist unwanted adsorption of proteins, microorganisms and other biological material. The coatings also allow selected biomolecules to be immobilised, enabling a surface to reject background contamination while retaining a specific recognition function. This combination is relevant to biosensors, diagnostic assays and bioinert material surfaces. The development work addresses adaptation to practical substrates and licensing of the coating platform for defined uses.
Gammahedron Directional Radiation Detector
Gammahedron is a directional ionising-radiation detector built around four sensors arranged in a tetrahedral geometry with shielding between them. A source illuminates the sensors differently depending on its direction, producing a characteristic response pattern. Simulation-generated response data are intended to train a machine-learning model that estimates source direction from the simultaneous sensor readings. The concept aims to provide real-time directional information without mechanically rotating the detector.
Gold Nanocluster Fluorescence Labels
Gold nanoclusters are developed as fluorescent labels with strong resistance to photobleaching and favourable separation between excitation and emission wavelengths. These properties are intended to support longer observations and clearer signals in microscopy and sensing. Further development work explores time-resolved lateral-flow and plate-based immunoassays as specific diagnostic formats using the same fluorophore platform. The offering includes nanocluster chemistry and assay-development know-how, with commercial feasibility and further validation still being assessed.
Graphene Membranes and Microscopy Supports
This manufacturing process produces large-area graphene by chemical vapour deposition, releases the atomically thin material from its growth substrate and transfers it onto delicate target structures. It enables free-standing membranes and specimen-support substrates for transmission and scanning electron microscopy. The membrane and support products build on graphene-transfer know-how originally developed for electron detectors, offering a separate consumable product line for microscopy laboratories and instrument suppliers.
Graphene-Enhanced Electron Detectors
This process grows high-quality graphene by chemical vapour deposition and transfers it onto the active area of electron-microscope detectors. Controlled growth, chemical release from the copper substrate and handling of the fragile layer are combined into a detector-adaptation workflow. The technology is intended to improve detector performance through a very thin functional graphene layer. It forms a separate application of the institute’s graphene-production platform from the membranes and specimen supports developed in later development work.
HistoryLab Inquiry-Based History Learning
HistoryLab combines a digital learning environment with an inquiry-based method for working with historical sources. Students analyse evidence, compare interpretations and develop historical reasoning through structured exercises, while teachers receive supporting materials and classroom workflows. The development activities address use in schools and cooperation with archives and museums, followed by English-language content and tools for wider dissemination. The offering consists of both the software platform and the educational methodology built around it.
Hybrid Coagulant for Water Treatment
A tailored hybrid coagulant brings contaminants in water together into flocs that can be removed by sedimentation, flotation or filtration. The formulation is designed to work across a broad pH range, including cold-water conditions, and can be adjusted to the composition of a particular raw-water source. The underlying preparation and dosing know-how targets drinking-water treatment as well as wastewater cleaning and reuse, supported by pilot-scale production and customer testing described in the development work.
Hydraulic Compressed-Air Energy Storage
A patented energy-storage concept combines compressed air with water-filled cylinders and controlled hydraulic displacement. During energy recovery, compressed air drives water through the system rather than relying on the conventional hot-air expansion arrangement. Pressure sensors, level sensors and controlled valves coordinate operation, supported by a mathematical model. The development work presents a route to stationary energy storage that aims to avoid external reheating during discharge and reduce dependence on large elevation differences between reservoirs.
IBOT Pearl Rubber-Producing Dandelion
IBOT Pearl is a bred dandelion cultivar intended as an alternative source of natural rubber and inulin. It combines relatively high biomass with stable reproduction without pollination, helping preserve useful traits across generations. The development work describes seed material and laboratory characterisation, while commercial cultivation and processing would be developed with industrial partners. The transferable asset is the plant material and associated breeding know-how, rather than a complete rubber-processing production line.
Impulse Exciter for Bridge Testing
A mechanical excitation device applies repeated force pulses to a bridge so that its structural response can be measured and analysed. It is intended to make dynamic testing of ageing bridges more efficient and less costly. The development work covers engineering a demonstrable prototype, laboratory calibration and testing on a real bridge. The exciter works alongside a separate deformation-measurement device developed in the same project, but represents its own instrument component and licensing opportunity.
Inorganic Casting and Sacrificial Moulds
A related family of forming methods uses polymer 3D moulds, refractory inorganic moulds and self-disintegrating mould systems to produce ceramic, metallic or geopolymer objects. The processes are intended to make complex shapes and larger assemblies easier to manufacture, including artistic reproductions and casting applications. Some formulations can incorporate secondary raw materials. The development work presents several separately transferable know-how packages, with further validation and partner-specific process development forming part of commercial introduction.
Integrated Archaeological Collections Data
This data-integration solution links archaeological fieldwork records and documentation with museum collection-management systems. It connects the AIS CR/AMČR research infrastructure with museum workflows, initially through collaboration with a collection-system supplier. Shared technical interfaces and methodological guidance are intended to reduce duplicate entry, preserve links between finds and their original context, and improve access to archaeological holdings. The offering serves archaeologists, museum curators, heritage institutions and users of open cultural data.
Label-Free iSCAT Molecular Imaging
Interferometric scattering microscopy observes nanoscale objects through the light they scatter, allowing sensitive imaging without fluorescent labelling. The development work explores wider use of the platform for real-time studies of molecular behaviour, interactions and biosensing beyond its existing mass-photometry market. It targets research and industrial users who need spatial and dynamic information from small biological or nanoscale objects. The offering combines optical instrumentation, measurement know-how and development of application-specific analysis workflows.
Laser Shock Peening for Durable Metals
Laser shock peening uses short, high-energy laser pulses to generate pressure waves that introduce compressive residual stress beneath a metal surface. A controlled treatment station and robotic handling apply the process to selected regions of a component. The induced stress field is intended to resist crack initiation and propagation, supporting improved fatigue and stress-corrosion behaviour. The development work examines industrial use of the process, including variants for difficult geometries and treatment without a sacrificial coating.
Laser-Based Inorganic Powder Printing
An experimental additive-manufacturing route processes inorganic powders with a laser to form shaped objects. The approach is intended to enable affordable, non-combustible parts, potentially using some secondary raw materials and allowing subsequent surface functionalisation. Proposed outputs include complex technical shapes, ceramic-like components and catalyst supports. The development work describes proof-of-concept work and the need for laboratory validation, materials development and assessment of suitable commercial uses before broader deployment.
Laser-Textured Moulds for Functional Plastics
Laser processing creates fine micro- and nanostructures on injection-mould surfaces, which are then transferred to plastic parts during moulding. Surface geometry can be used to alter properties such as wetting, friction, adhesion, optical behaviour and interactions with biological material without relying solely on additional chemical coatings. The development work describes laboratory testing with industrial polymers and a route towards manufacturing partners. Commercial performance depends on the structure, polymer and moulding conditions for each product.
Live-Cell Magnetic Hyperthermia Imaging
A laboratory platform combines a magnetic-field-generating coil with advanced live-cell microscopy to study how magnetic nanoparticles and heating affect tumour cells. Integration with Q-Phase microscopy allows the same cells to be observed before, during and after exposure, including changes in shape, growth and movement without staining. The setup can also support studies combining hyperthermia with cytostatic drugs. The development work concerns a research instrument at an early validation stage, not a clinical treatment device.
Low-Consumption Liquid-Nitrogen Cooling
A modular liquid-nitrogen bath cooling system is designed for sustained, stable cooling in cryogenic electron microscopy and related analytical instruments. The approach aims to reduce nitrogen consumption and the frequency of refilling while remaining adaptable to different microscope configurations. It can support integration into new equipment or conversion of existing instruments for cryogenic work. The development work also identifies individual components that could be supplied separately for other scientific cooling requirements.
Low-Valent Carbon Photocatalysts
Photoactive low-valent-carbon compounds support light-driven energy and electron transfer for the synthesis of fine chemicals. The development work describes proof-of-concept chemistry intended to offer an alternative to photocatalysts based on expensive heavy metals such as iridium or ruthenium. The technology concerns catalytic molecules and reaction know-how for producing specialised organic building blocks. Commercial development would require validation for selected reactions, assessment of practical process conditions and cooperation with chemical producers.
Micro- and Nanocellulose Production
A water-based mechanical separation method converts cellulose feedstocks into microfibrillated cellulose and cellulose nanofibres. It is designed to work with renewable raw materials, including suitable waste-derived sources, and builds on a process developed with CEMEA of the Slovak Academy of Sciences. The resulting fibres can serve as reinforcement, barrier materials or formulation additives. The development work considers uses in paper and packaging, polymer composites, textiles and personal-care products, with commercial performance requiring material-specific qualification.
Microbial Phytocomplex Separation
A countercurrent separation platform produces bioactive fractions, termed Phytocomplexes, from microalgae and other microorganisms, including yeast-derived material. The process aims to retain useful combinations of naturally occurring compounds while reducing unwanted components, rather than isolating a single ingredient. Selected processes have been developed with industrial partners, including use of food-compatible solvent systems. The resulting fractions are being evaluated as ingredients for cosmetics, dermatology, food, feed and nutraceutical products.
Microwave Synthesis of ZnO Nanotetrapods
Microwave irradiation of zinc-oxide powder generates local electrical discharges that drive decomposition and recombination into four-armed zinc-oxide nanostructures. The resulting nanotetrapods are collected from the aerosol produced above the reaction zone. The development work describes a comparatively simple synthesis route and characterisation of the material and discharge mechanism. The manufacturing know-how targets functional ZnO materials for uses such as sensing, photonics, polymer composites and biomaterial development, subject to application-specific validation.
MINED Clinical Signal Data Management
MINED links anonymised patient information, electrophysiological recordings and associated clinical metadata in a structured relational database. A web interface allows users to navigate, manage and perform selected analyses without programming expertise. The development work describes use with both scalp and intracranial EEG, emphasising data consistency, secure access and collaboration between institutions. MINED complements NeuroView by providing the organised data-management foundation beneath signal review and research workflows.
Minoxidil-Based Antifibrotic Formulations
The research explores minoxidil and modified formulations referred to as M+ as potential non-invasive treatments for fibrotic conditions, particularly Dupuytren’s contracture. It builds on laboratory observations of antifibrotic activity and investigates whether specific combinations of the active substance and additives can form a protectable therapeutic product. Formulation development, intellectual-property assessment and preparation for clinical evaluation are central steps; the development activities describe a development candidate, not an established treatment.
Multiwavelength Optical Surface Metrology
Multiwavelength interferometry supports precise measurement of the shape and other parameters of optical surfaces. The development work describes know-how for a fast, largely automated instrument targeting flat, spherical and aspherical components, including surface-radius measurement and possible integration into semi-automated production lines. The proposed system aims for nanometre-scale resolution and repeatability. The technology combines optical design, measurement principles and control software, with further engineering required before an industrial product is ready.
Nanostructured Industrial Catalysts
A portfolio of zeolite and perovskite catalysts supports cleaner and more efficient industrial chemical processes. The development activities describe catalysts for nitrogen-oxide and nitrous-oxide abatement, hydroisomerisation of light hydrocarbon fractions and benzene alkylation. Different formulations target different reactions and operating conditions, with selected catalysts already tested or used at industrial scale in the reported work. The transferable offering combines catalyst compositions, preparation methods, process know-how and technical support for industrial deployment.
NeuroView Collaborative EEG Analysis
NeuroView is a browser-based environment for viewing, annotating and analysing large electrophysiological recordings. Its web interface is intended to make technically complex signal data accessible to clinical and research users without local software installation. The system supports simultaneous work by users at different locations while controlling access to underlying data. It is one of two complementary tools in the RDPipe/WaveSurfers project, addressing the visual and collaborative analysis layer of biomedical signal workflows.
Neutral-Beam Heating for Fusion Research
A neutral-beam injection system delivers an energetic particle beam for auxiliary heating of plasma in experimental fusion devices. The development work focuses on systems sized for small and medium research facilities, where equipment developed for very large fusion projects may be unsuitable. The transferable offering combines system engineering, component knowledge and technical documentation for customer-specific implementation. Commercial preparation addresses potential research-institute, university and private fusion-development customers and an appropriate licensing model.
Next-Generation Antivenom Production
A production platform combines venom preparation and fractionation, animal immunisation and antibody-processing methods to develop polyvalent or polyspecific antivenoms. The development work includes pilot work on selected snake venoms and explores production routes involving chickens alongside the institute’s other immunological capabilities. The objective is to improve the specificity and tolerability of antibody-based products for human or veterinary use. This is a development platform requiring validation, manufacturing qualification and regulatory progression, rather than an approved medicine.
Nucleoside-Depleting Anticancer Proteins
Experimental recombinant proteins alter the availability of extracellular nucleosides, restricting a supply route used to support tumour growth. The development work describes in-vitro activity and evidence from a mouse lung-cancer model, together with a strategy for intellectual-property protection and further development. The proposed therapeutic approach targets tumour metabolism through a protein-based mechanism. Additional disease applications are discussed as possibilities, while clinical efficacy, safety and practical treatment use remain unestablished.
Optical Micro-Concentrators for Detector Arrays
Refractive, quasi-parabolic micro-optical structures concentrate incoming light onto the active regions of optical detector arrays, particularly single-photon avalanche diodes with a low active-area fraction. The design aims to improve effective light collection without changing the detector chip itself. Prototype structures have been produced using high-resolution three-dimensional printing, while fabrication accuracy and measured performance remain development tasks. The technology is intended for integration by detector and optical-system manufacturers.
PerfLab Quantitative Perfusion MRI
PerfLab analyses dynamic contrast-enhanced magnetic resonance imaging data to produce quantitative maps of tissue perfusion. Its algorithms combine advanced pharmacokinetic models, estimation of the arterial input signal and spatial information from neighbouring tissue to improve parameter estimation. The software is designed to make sophisticated analysis accessible through a user-friendly workflow, including browser-based delivery. Applications include cancer-imaging research and the development of more objective assessment tools, with later work focusing on prostate cancer.
Phase-Resolved Mass Photometry
A specialised interferometric-scattering microscope measures amplitude, phase and polarisation of light scattered by very small objects. A phase or polarisation mask in the imaging path encodes additional information beyond conventional intensity-based mass photometry. Amplitude can be related to molecular mass, while phase offers information about material properties and vertical position. The development work targets quantitative single-biomolecule analysis and improved structural interpretation, using laboratory-validated optical designs and a prototype instrument configuration.
Písňovna Folk-Music Heritage Platform
Písňovna makes archival folk-song and related musical material accessible through a digital platform and associated educational resources. Earlier development work develops teaching-oriented content, transcription and interpretation of historical records. The later Naše Písňovna proposal adds participatory work with handwritten musical and textual sources, supported by transcription technologies and community contributions. Together, the development activities connect scholarly archival expertise with practical use by teachers, musicians, cultural organisations and the public.
Plasma Spheroidisation of Ceramic Powders
A plasma-processing service converts irregular ceramic powder particles into more spherical, free-flowing material using WSP-H technology. The proposed workflow combines selection of processing conditions, spheroidisation, classification and basic powder-quality checks. Existing development work covers oxidation-tolerant ceramics such as alumina, YSZ and YAG. The technology targets powder users who require more predictable flow and handling, including additive-manufacturing and coating applications; broader material coverage remains a development direction.
POSED Portable Chemical Analysis
POSED combines membrane extraction with electrochemical detection in a portable analytical device. The membrane and extraction medium can be chosen to concentrate selected contaminants from complex samples such as wastewater or polluted river water before measurement with standard printed electrodes and portable analysers. The platform targets trace chemicals including pesticides, industrial substances, pharmaceuticals and their metabolites. It is intended to bring adaptable, low-consumable chemical monitoring closer to field and routine laboratory use.
PRINTONAUT Automated 3D-Print Quoting
PRINTONAUT is a software platform for preparing, assessing and pricing three-dimensional printing jobs online. It is intended for integration into print-centre websites so customers can submit models and parameters while providers automate parts of quotation and production preparation. The development work describes a beta-stage supplier workflow and commercial testing with print centres. Transferable components include model-handling tools, job-preparation functions and the software integration and licensing package.
Pulsating Waterjet Hull Cleaning
High-speed pulsating water jets remove deposits, coatings and surface layers using clean water without abrasive additives. The technology is intended to increase the disruptive effect of a continuous jet while avoiding spent abrasive material and limiting thermal effects. The development work focuses on an industrial cleaning tool for ship hulls, including removal of biological fouling and other accumulations. The transferable package combines jet-generation expertise, tool design and operating procedures for marine maintenance.
qPCR Monitoring of Fish Pathogens
A real-time quantitative PCR approach detects and measures fish pathogens directly from water or minimally invasive samples such as skin swabs. The method is intended to identify bacteria, parasites or viruses before an outbreak becomes apparent in intensive aquaculture. Repeated measurements can be combined with information about water conditions to inform management decisions. The development work covers adaptation to different pathogens and development of a service model for fish-farm surveillance and intervention planning.
Reaction-Based Inorganic 3D Printing
Reaction-based inorganic additive manufacturing builds shaped objects from inorganic material systems, with an emphasis on non-combustible, durable and potentially recyclable outputs. The development activities describe development of printing know-how, materials and representative samples for technical components, refractory uses, artistic objects and replicas. Later RA3DT development concentrates on the reaction-based process and its licensing package. Industrial adaptation remains application-specific, including the choice of material formulation, part geometry and performance requirements.
Reprocessable Bio-Based Polymer Foams
Plant-oil-derived precursors form foams based on dynamic vinylogous urethane bonds without using isocyanates or an added catalyst. The development work describes room-temperature preparation and the ability to vary mechanical properties from elastic to rigid foams. Dynamic bonding also offers a route to thermal reprocessing and material recycling. The technology concerns formulations and process know-how for future foam products, with pilot manufacture, long-term performance and application-specific validation still to be established.
Research-Based Humanities Teaching Framework
A coordinated educational framework translates the humanities and social-science expertise of several institutes into materials and activities suitable for secondary schools. The project addresses how content should be selected, labelled and presented around teachers’ practical and didactic needs, including connections between literature, history and philosophy. Proposed approaches are to be tested with educators and relevant public bodies. The transferable offering is a research-informed teaching and communication methodology, supported by the institutes’ educational content.
RF Plasma Diagnostics for Coating Processes
A radio-frequency probe system measures electrical waveforms in low-pressure plasma and uses physical models to estimate plasma parameters such as ion flux, ion concentration and electron temperature. Unlike conventional approaches sensitive to surface contamination, the proposed probe can operate with dielectric or semiconducting layers deposited on its surface. The substrate itself can also act as a measuring surface. The technology is intended for diagnostics and control of plasma-assisted coating and related deposition processes.
Scientific Software Licensing Platform
A shared online distribution and licensing platform supports access to scientific software developed at the institute, including PETS2, JANA2020 and CrysTBox. The project combines an e-shop with clearer licensing conditions and internal commercialisation procedures so that users can identify, obtain and receive support for relevant software. Its transferable output is the delivery and management infrastructure surrounding these scientific applications, together with procedures that can accommodate additional software products.
Sector-Specific Corruption-Risk Assessment
A social-science methodology turns sector-level evidence about corruption mechanisms into a repeatable analytical process for public administration. The approach seeks to move from broad perception measures towards specific experiences and mechanisms within individual sectors. The development work focuses on standardising the procedure so that public institutions can repeat the assessment and use its findings in policy evaluation. The transferable offering is an analytical method, implementation guidance and associated expertise, rather than a physical technology.
Selective Galectin-1 Cancer Inhibitors
RuTDG and BuRuTDG are experimental carbohydrate-based compounds modified with organoruthenium complexes to selectively inhibit galectin-1. The two compounds are designed to address extracellular and intracellular activity, respectively, including mechanisms associated with tumour immune suppression and chemotherapy resistance. The development activities focus on their potential as additions to treatment for triple-negative breast cancer. Evidence described is preclinical; the transfer opportunity concerns further drug development, validation and partnership with pharmaceutical developers.
Selective Waterjet Surgery
A surgical instrument uses a precisely controlled, high-speed liquid jet to remove selected tissue without the heat generated by conventional cutting methods. The development activities focus on removing the epidermis during breast-reduction surgery while preserving the underlying dermis. Early laboratory, ex-vivo and animal work informs nozzle design and operating parameters. The technology is being developed towards a reproducible surgical device, with safety, regulatory qualification and clinical validation forming part of its route to use.
Self-Stabilising Water-Filled Flood Barriers
A single-chamber flood-protection bag incorporates an internal structure designed to resist rolling under water pressure. The concept aims to avoid the need for external wedges, anchoring, support walls or tying multiple bags together, making deployment faster and simpler. A small-scale bag has been tested with an industrial partner in the reported work. The transferable technology covers barrier construction and design know-how, with larger-scale and certified testing still required before wider deployment.
SharpED Electron-Density Map Enhancement
SharpED applies a three-dimensional neural network to improve electron-density maps produced by X-ray diffraction analysis. Cleaner maps can make crystal structures easier to interpret and support more reliable structural analysis of crystalline substances. The software is designed for integration into existing crystallographic workflows rather than requiring a new measurement instrument. The development work describes testing on real data and preparation of academic and commercial licensing arrangements for software and instrument partners.
ShinyItemAnalysis Psychometric Analytics
ShinyItemAnalysis provides interactive tools for evaluating tests, questionnaires, individual assessment items and rater data. The open-source core supports psychometric analysis through accessible interfaces, while domain-specific modules, integration, training and support can be delivered as commercial services. Its intended uses span educational testing, recruitment, certification and health-outcome measurement. Successive development activities develop the route from an established research software package to an organised service and support offering.
Silyl-Functionalised Polyethylene Synthesis
A catalytic polymerisation process uses hydrosilanes both in catalyst activation and as chain-transfer reagents to introduce silyl groups at polyethylene chain ends. This combines control of chain length and terminal functionalisation during polymer formation, potentially simplifying production by reducing subsequent modification steps. The development work considers materials with tailored reactivity for uses such as adhesion, controlled crosslinking and functional polymer products. Industrial performance remains dependent on formulation, process optimisation and validation with partners.
Solid-Immersion TIRF Microscopy Module
A compact microscopy module uses a solid hemispherical immersion lens and side illumination to enable total internal reflection fluorescence imaging on a conventional optical microscope. Light reaches the specimen independently of illumination through the objective, while the high-index lens increases effective optical performance. The module also supports other imaging modes, including dark-field and interference-reflection imaging. It originated within a correlative-microscopy project but is being developed as an independently usable component.
Spark-Ablated Catalyst Coatings
Spark ablation generates metal nanoparticles for controlled deposition of functional layers, including mixtures with polymer-electrolyte binder. The development work focuses on catalytic layers for low-temperature hydrogen fuel cells and related hydrogen technologies. The transferable know-how combines nanoparticle production, coating uniformity and formulation of the functional layer into a manufacturing process. Commercial preparation centres on equipment and process transfer through the proposed Ignia Technologies spin-off and cooperation with industrial partners.
Species-Selective Insect Growth Regulators
A library of compounds mimics the action of insect juvenile hormone and interferes with development and metamorphosis. The research identifies compounds that recognise hormone receptors differently across insect species, creating the possibility of targeting selected pests while limiting effects on non-target insects. Some compounds have been tested in living insects in the reported work. The transferable assets include chemical leads, screening knowledge and development expertise for future selective pest-control products.
Spectra Sense Solar-Cell Defect Imaging
Spectra Sense uses time-resolved fluorescence analysis and the RATS measurement method to investigate defects in perovskite and tandem solar-cell materials. The approach is designed to observe material behaviour under illumination conditions closer to normal operation than conventional pulsed measurements, reducing misleading interpretation caused by the measurement itself. The intended offering includes analytical services and microscopy hardware. Successive development activities address customer validation, pilot use and standardised interpretation of defect measurements.
Thermal-Plasma Carbon Nanotube Production
An atmospheric-pressure thermal-plasma system produces carbon nanotubes from hydrocarbon feedstocks using transition-metal catalysts. The development work describes a scalable synthesis route intended to combine productive output with control of nanotube quality and defects. The transferable technology includes reactor operation, catalytic processing and associated manufacturing know-how. The planned commercial offering concerns nanotube materials for further qualification in applications such as conductive composites, electronics and energy-storage components.
Titanium-Dioxide Sorbents for Water Treatment
Titanium-dioxide-based sorbent materials are designed to remove manganese and other heavy metals from water in a single treatment step. The approach seeks to simplify treatment compared with combinations of oxidation and separation processes, especially where controlling water chemistry is difficult. Preparation of the sorbent has been explored at pilot scale, while practical deployment is being developed with a partner. The transferable package covers material preparation and the conditions needed for its use in water treatment.
Two-Tailed Primer Studio RNA Assay Design
Two-Tailed Primer Studio automates the design of specialised two-armed primers for Two-Tailed RT-qPCR assays targeting short RNA molecules. The software addresses a complex design task that otherwise restricts broader use of the underlying detection method. It is intended to help assay developers and primer manufacturers create selective RNA tests more efficiently through a business-to-business software offering. The development work covers technical presentation, commercial validation and licensing preparation for the design platform.
Ultraweak Biological Light Detection
Light-tight measurement chambers, highly sensitive photon detectors and calibrated acquisition procedures detect extremely low light emissions from biological samples. The platform is intended to support reproducible studies of subtle oxidative, metabolic or physiological changes without fluorescent labelling or destruction of the sample. The proposed commercial package combines instruments, standard operating procedures, data processing and measurement services. The development work explicitly positions initial use in research and development rather than as an established clinical diagnostic.
VOC Gas-Mixture Calibration Generator
Parallel flow paths and diffusion cells generate mixtures of volatile organic compounds with defined composition and different concentrations. The device is intended to provide stable, flexible gas streams for calibrating analytical instruments such as mass-spectrometric, chromatographic and photoionisation systems. It supports laboratory method development as well as environmental and industrial measurement workflows. The development work covers transfer of the instrument design and operating know-how, including preparation for patent protection and commercial manufacture.
Water-Based Exfoliation of 2D Materials
A mechanical separation process uses a water-based exfoliation medium to produce thin sheets from layered materials. Laboratory work described in the development work includes graphene and boron-nitride nanosheets, with properties determined by the starting material and resulting layer structure. The process is intended to make functional two-dimensional materials available for further development in composites, thermal management, electrical insulation, sensing and other uses. The technology was developed with CEMEA of the Slovak Academy of Sciences.
Wildlife Disease Monitoring Platform
A proposed digital workflow connects hunters, hunting-ground managers and veterinary authorities for reporting, sampling and managing infectious diseases in wildlife. It transfers findings from research on the social organisation of veterinary surveillance into practical communication and data flows. The pilot focuses on mandatory trichinellosis sampling in hunted wild boar, with scope for broader disease monitoring. The offering combines software integration with user-centred procedures for sample handling, reporting and biosecurity coordination.